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What Individuals Want to Hear at the Point of Type 2 Diabetes …

Details: Recent studies have shown that the time of diagnosis with type 2 diabetes is often not a teachable moment because of heightened emotions. Yet, research also shows that individuals who are newly diagnosed with type 2 diabetes need reassurance and a clear pathway to obtain the education and support needed to self-manage the condition.

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Management and Outcomes of Severe Hypoglycemia Treated by …

Details: We retrospectively analyzed electronic health records of a multistate advanced life support EMS provider and an integrated healthcare delivery system serving an overlapping geographic area in the upper Midwest. For adults with diabetes treated by EMS for hypoglycemia between 2013 and 2019, we examined rates of ED transport, factors associated

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› Url: https://diabetesjournals.org/care/article/doi/10.2337/dc21-1811/147111/Management-and-Outcomes-of-Severe-Hypoglycemia Go Now

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Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose …

Details: Leptin, a hormone secreted by adipocytes, exhibits therapeutic potential for the treatment of insulin-dependent diabetes mellitus (IDDM). Protein tyrosine phosphatase 1B (PTP1B) is a key enzyme that negatively regulates leptin receptor signaling.

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› Url: https://diabetesjournals.org/diabetes/article/doi/10.2337/db21-0953/147141/Protein-Tyrosine-Phosphatase-1B-Deficiency Go Now

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Frequency of Ketoacidosis at Diagnosis of Pediatric Type 1 …

Details: Children and adolescents aged ≤18 years, living in Germany, with newly diagnosed type 1 diabetes documented between 2016 and 2019 in the Diabetes Prospective Follow-up Registry (DPV; Diabetes-Patienten-Verlaufsdokumentation), were assigned to a quintile of regional socioeconomic deprivation (German Index of Socioeconomic Deprivation) and to a …

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Changes in the Co-Expression of Innate Immunity Genes During …

Details: 1 Department of Epidemiology, Colorado School of Public Health; 2 Barbara Davis Center, Department of Pediatrics, University of Colorado Anschutz Medical Campus; Corresponding Author: Jill M. Norris, MPH, PhD, Department of Epidemiology, Colorado School of Public Health, 13001 E 17th Avenue Pl, Mail Stop B119, Aurora Colorado 80045, Jill.Norris

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Fat-distribution Patterns and Future Type-2 Diabetes

Details: We therefore investigated fat-distribution patterns and their link to future T2D. From 2168 individuals without diabetes who underwent computed tomography in Japan, this case-cohort study included 658 randomly selected individuals and 146 incident cases of T2D over 6 years of follow-up. Using data-driven analysis (k-means) based on fat content

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› Url: https://diabetesjournals.org/diabetes/article/doi/10.2337/db22-0315/147108/Fat-distribution-Patterns-and-Future-Type-2 Go Now

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Brief Pictorial Quizzes to Assess Carbohydrate Counting and …

Details: Available assessments of patient nutrition knowledge and carbohydrate counting ability are lengthy. This article reports on a study to implement and validate a series of brief nutrition quizzes of varying difficulty for use in pediatric type 1 diabetes.

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Fasting Substrate Concentrations Predict Cardiovascular Outcomes …

Details: 4 The George Institute for Global Health, University of New South Wales (UNSW) Sydney, Sydney, Australia. Search for other works by this author on: This Site. PubMed. Google Scholar. Bruce Neal. 0000-0002-0490-7465 ; Bruce Neal 4 The George

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› Url: https://diabetesjournals.org/care/article/doi/10.2337/dc21-2398/147112/Fasting-Substrate-Concentrations-Predict Go Now

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Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but …

Details: Mitochondria are often referred to as the powerhouses or “chief executive organelles” of the cell, using fuels to provide most of the energy required to sustain normal function ().Mitochondrial oxidative metabolism plays a pivotal role in the response of pancreatic β-cells to stimulation by glucose and other nutrients ().Thus, as blood glucose increases, …

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Leptin Signaling Suppression in Macrophages Improves …

Details: Obesity is a major concern for global health care systems. Systemic low-grade inflammation in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the adipose tissue that functions by controlling food intake, leading to satiety. Leptin levels are increased in obesity.

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› Url: https://diabetesjournals.org/diabetes/article/71/7/1546/144973/Leptin-Signaling-Suppression-in-Macrophages Go Now

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β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic

Details: This work was supported by National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants (R01 DK101530, R01 DK119955, and P30 DK116074) and JDRF (2-SRA-2019-800-S-B) to J.P.A. S.L. received funding from an NIDDK Endocrinology Training grant (T32 DK007217) and Stanford Child Health Research

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› Url: https://diabetesjournals.org/diabetes/article/71/7/1439/145039/Cell-Succinate-Dehydrogenase-Deficiency-Triggers Go Now

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GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Details: A major challenge of current and novel weight loss medications is the occurrence of nausea and vomiting (1–3).These physiological responses can occur due to drug-mediated overstimulation of anorectic pathways and/or the recruitment of aversive/emetic circuits that naturally defend against the consumption of toxic substances (4–6).Aversive/emetic responses …

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Endothelial Prohibitin Mediates Bidirectional Long-Chain Fatty …

Details: All animal experimentations were approved by the University of Texas Health Animal Care and Use Committee. Mice were housed in the animal facility with a 12-h light/dark cycle at a temperature of 22–24°C, with free access to water and diet. PHB1 fl/fl and TIE2e-Cre mice were used for generating KO mice.

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Circulating C-Peptide Levels in Living Children and Young People …

Details: Circulating C-peptide, a marker of endogenous insulin secretion from pancreatic β-cells, is known to decline following a diagnosis of type 1 diabetes, but can persist for many years (1–8).It is frequently observed, however, that those diagnosed at the youngest ages have lower levels of C-peptide at diagnosis (2,3,5,6,9).Histological analyses of donor pancreata …

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Botulinum Injection Into the Proximal Intestinal Wall of Diet …

Details: The mice remained under the care of the Division of Animal Care in compliance with National Institutes of Health guidelines and the Association for Assessment and Accreditation of Laboratory Animal Care. Male C57BL/6J mice were purchased from The Jackson Laboratory and housed at 23°C on a 0700–1900-h light cycle and were fed a high-fat diet

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