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New approach can help identify young children most at …

WEBUNIVERSITY PARK, PA. — Newly developed risk scores synthesize genetic information into an easy-to-interpret metric that could help clinicians identify young …

Actived: 9 days ago

URL: https://www.bx.psu.edu/makova_lab/press_release/2022-01-10/

Childhood obesity The Makova Lab at Penn State

WEBChildhood obesity. Jan 8, 2018. Obesity is becoming the major epidemic of the 21st century, and we are studying this disease in an integrated way - from the perspective of …

Category:  Health Go Health

Young children’s oral bacteria may predict obesity

WEBThe composition of oral microbiota – the collection of microorganisms, including beneficial bacteria, residing in the mouth – in two-year-old children may predict …

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A new class of functional elements in the human genome

WEBSome regions of the human genome where the DNA can fold into unusual three-dimensional structures called G-quadruplexes (G4s) show signs that they are …

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A Syllabus of Human Hemoglobin Variants (1996)

WEBA Syllabus of Human Hemoglobin Variants (1996) Browse; Simple text search; Query the HbVar database; Feedback. A Syllabus of Human Hemoglobin Variants (1996), by Titus …

Category:  Health Go Health

Unusual DNA folding increases the rates of mutations

WEBDNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New …

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How to contact us

WEBHow to contact us. If you have any questions, comments, suggestions, bug reports, or need assistance, please send e-mail to one of the following: For PipMaker or MultiPipMaker : …

Category:  Health Go Health

Methylation profiles at birth linked to early childhood …

WEBChildhood obesity represents a significant global health concern and identifying risk factors is crucial for developing intervention programs. Many 'omics' …

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The Makova Lab at Penn State

WEBSarah is interested in human evolution with a specific emphasis on genetic variation within and between species, gene duplication, and the evolution of regulatory elements. She …

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DNA sequence of the human Y chromosome fully …

WEBListen to the Science Friday podcast where Adam Phillippy and Kateryna Makova discuss the challenges of sequencing the Y chromosome, and what doing so …

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A Population Phylogenetic View of Mitochondrial Heteroplasmy

WEBThe mitochondrion has recently emerged as an active player in myriad cellular processes. Additionally, it was recently shown that >200 diseases are known to …

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New mutations accumulate in reproductive cells of older mice

WEBOlder mice have more new mutations – changes in DNA sequence that occur in the individual rather than being inherited from a parent – than younger mice in the …

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Scientists take a step toward understanding 'jumping genes' effect …

WEBComparisons of DNase Hypersensitive Site (DHS) signals among L1 flanking regions and control.The figure illustrates the distribution of one genomic feature …

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Investigating mitonuclear interactions in human admixed …

WEBOur results provide the first evidence of mito-nuclear effects in human admixed populations and we discuss its implications for human health and disease. To …

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The Makova Lab at Penn State

WEBXinru is a Ph.D. student in the Bioinformatics and Genomics Program co-advised by Dr. Kateryna Makova and Dr. Yi-Fei Huang. Currently, she’s been studying the evolution of …

Category:  Health Go Health

Are egg cells in aging primates protected from mutations

WEBA new study shows that mutation frequencies in mitochondrial DNA are lower, and increase less with age, in the precursors of egg cells than in the cells of other …

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Phylogenomic Resources at the UCSC Genome Browser

WEBto support certain hypotheses about phylogenetic relationships, such as that the human lineage diverged from dogs and cows before it diverged from mice (12), and that horses …

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Whole-Genome Sequencing (WGS)

WEBSequence signatures of structural variation • Read pair analysis • Deletions,small novel insertions,inversions, transposons • Size and breakpoint resolution dependent to insert …

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IMPROVED PAIRWISE ALIGNMENT OF GENOMIC DNA

WEBWe applied the iterated inference procedure of section 5.4 to 135 simulated sequence pairs (section B.2). Of interest was whether the process would converge and if so whether the …

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