Cmbl.biomedcentral.com

Ubiquitous protein lactylation in health and diseases

WebFor decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not …

Actived: 6 days ago

URL: https://cmbl.biomedcentral.com/articles/10.1186/s11658-024-00541-5

Osteoporosis pathogenesis and treatment: existing and …

WebOsteoporotic fractures lead to increased disability and mortality in the elderly population. With the rapid increase in the aging population around the globe, more …

Category: Health Go Health

An overview of current drugs and prophylactic vaccines …

WebDesigning and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 …

Category: Coronavirus Go Health

Cellular senescence in skeletal disease: mechanisms and …

WebThe musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the balance of …

Category: Health Go Health

Unlocking the secrets: exploring the influence of the aryl …

WebGut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with …

Category: Health Go Health

Osteoporosis pathogenesis and treatment: existing …

WebCurrently, the available clinical treatments for osteoporosis have mostly focused on factors influencing bone remodeling; however, they have their own limitations and side efects. …

Category: Health Go Health

The NLRP3 inflammasome: contributions to inflammation …

WebThe NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory …

Category: Health Go Health

Uremic toxins mediate kidney diseases: the role of aryl …

WebAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed …

Category: Health Go Health

Insight into the physiological and pathological roles of …

WebThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of …

Category: Health Go Health

Osteoporosis: the current status of mesenchymal stem …

WebOsteoporosis, a bone disease involving the appearance of porous bone, is characterized by low bone mass and microarchitectural deterioration of bone tissues, …

Category: Health Go Health

The role of mitochondrial dynamics and mitophagy in skeletal …

WebSkeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential …

Category: Health Go Health

Current prevalence status of gastric cancer and recent studies on …

WebGastric cancer is a malignant tumor with the fifth incidence and third mortality worldwide. There were 951,000 new cases and about 723,000 patients died of it in 2012. …

Category: Cancer Go Health

The nuclear receptor 4A family members: mediators in human …

WebThe Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and …

Category: Health Go Health

CRISPR–Cas9 applications in T cells and adoptive T cell therapies

WebT cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse …

Category: Cancer Go Health

The usefulness of lactate dehydrogenase measurements in current

WebOne of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in …

Category: Cancer Go Health

Molecular mechanisms underlying the renal protective effects of

WebMain molecular mechanisms of the renal protective effects developed by CoQ10 in different types of AKI. CoQ10 is an endogenous antioxidant. Under AKI …

Category: Health Go Health

Comprehensive overview of COVID-19-related respiratory failure: …

WebThe pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Understanding the entry mechanism of this …

Category: Coronavirus Go Health

MYH1G-AS is a chromatin-associated lncRNA that regulates …

WebSkeletal muscle development is pivotal for animal growth and health. Recently, long noncoding RNAs (lncRNAs) were found to interact with chromatin through …

Category: Health Go Health

CRISPR/Cas9 gene editing: a new approach for overcoming drug …

WebThe CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide …

Category: Health Go Health