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mRNA Vaccines COVID-19: Evidence Based Medicine

WebDecember 1st, 2021. Two mRNA COVID-19 vaccines, produced by Pfizer-BioNTech (Comirnaty®) and Moderna (Spikevax®), were granted Emergency Use Approval (EUA) …

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URL: https://covidebm.umn.edu/mrna-vaccines

Monoclonal antibodies COVID-19: Evidence Based Medicine

WebPotential uses of mAbs directed against SARS-CoV-2 include preventing or treating COVID-19, both areas under ongoing active investigation. Virus-neutralizing monoclonal …

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Nirmatrelvir COVID-19: Evidence Based Medicine

WebThis medication is recommended. It is has been granted an emergency use authorization by FDA for the treatment of mild-to-moderate coronavirus disease (COVID-19) in adults and …

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Guidelines COVID-19: Evidence Based Medicine

WebGuidelines. The following is a list of COVID-related guidelines. Note that MHealth/Fairview clinicians should refer to documents on the intranet site first. For any questions or …

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Vaccine Reviews COVID-19: Evidence Based Medicine

WebIn large, placebo-controlled trials, vaccines currently authorized in the United States were efficacious for preventing COVID-19. Evidence-based reviews of the data that provide …

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BCG Vaccination COVID-19: Evidence Based Medicine

WebThe Bacille Calmette-Guérin (BCG) vaccine induces epigenetic reprogramming in human monocytes in vivo, followed by functional reprogramming and …

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Vitamin C COVID-19: Evidence Based Medicine

WebFebruary 14th, 2021. Vitamin C is a potent antioxidant and contributes to immune defence by supporting various cellular functions of the immune system. It is well documented that …

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Tocilizumab COVID-19: Evidence Based Medicine

WebJune 9th, 2021. Tocilizumab is a monoclonal antibody that targets both soluble and membrane bound IL-6 receptors, preventing IL-6 binding and reducing IL-6 signaling. It is …

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Therapy Reviews COVID-19: Evidence Based Medicine

WebTherapy Reviews. Evidence-based reviews summarizing the clinical data and rationale for several potential therapies for COVID-19 are summarized below by topic. Contact us at …

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Ribavirin COVID-19: Evidence Based Medicine

WebApril 19th, 2020. Activity of ribavirin against SARS-CoV-2 has been demostrated in vitro (Wang 2020), although it was found to be 100-fold less potent than remdesivir and …

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Convalescent Plasma COVID-19: Evidence Based Medicine

WebSARS-CoV2 Meta-Analysis: Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a living systematic review- Piechotta V, et al. Cochrane Database …

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Ivermectin COVID-19: Evidence Based Medicine

WebIvermectin is an anthelminthic that has some anti-viral properties. There is in vitro evidence of activity against SARS-CoV-2 in infected Vero-hSLAM cells with high …

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Vitamin D COVID-19: Evidence Based Medicine

WebFebruary 25th, 2021. It is well known that the COVID-19 virus puts a large strain on the immune system, and vitamin D is a known immune modulator. Specifically vitamin D acts …

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Aspirin COVID-19: Evidence Based Medicine

WebAspirin has anti-inflammatory, analgesic, antipyretic, and antithrombotic effects. It is well documented that thrombotic complications are frequent in those with COVID-19. The …

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Intravenous Immunoglobulin Therapy COVID-19: Evidence Based …

WebJune 7th, 2020. Intravenous immunoglobulin (IVIG) therapy can suppress a wide variety of autoimmune and chronic inflammatory diseases.

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JAK Inhibitors COVID-19: Evidence Based Medicine

WebCurrently, the JAK inhibitor Baricitinib has been found to be an approved treatment option for severe COVID-19 infections. JAK inhibitors have been proposed as …

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About the COVID EBM Team COVID-19: Evidence Based Medicine

WebMeet the UMN COVID-19 Learning Health System Team. Contact us at [email protected].

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Lopinavir/Ritonavir (Kaletra) COVID-19: Evidence Based Medicine

WebLopinavir/Ritonavir (Kaletra) Last review completed on. April 10th, 2020. Lopinavir-ritonavir is a combined protease inhibitor, which has primarily been used for …

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